Fondren Presbyterian Church received its charter in 1930. The church met in a house on the corner of State Street and Lorenz from September 1928 until December 1949 and moved to its present location, 3220 Old Canton Road, in January 1950.

Fondren is steeped in the traditions of community activism and service and currently supports many local and/or regional efforts through its Outreach ministries. Over the years, Fondren has provided a meeting place for a wide variety of community organizations and activities. Fondren has actively supported Presbytery relief efforts following Hurricane Katrina with a work team, monetary contributions, and casserole brigades. Fondren also supports the work of the Presbytery of Mississippi; the Synod of Living Waters, particularly the Living Waters Project; and the General Assembly of the PCUSA, specifically the Theological Education Fund and the Conference Center at Montreat, North Carolina.

Presently experiencing renewed growth, Fondren Presbyterian Church projects a future fully as rich as its past, continuing its tradition of love and service through nurturing its members and reaching out to the community in the name of Christ.